Liposomal NMN

What is NMN?

Nicotinamide Mononucleotide (NMN) is a direct precursor to NAD⁺ (nicotinamide adenine dinucleotide), a critical coenzyme in every living cell that declines ~50% between age 30 and 60. NAD⁺ fuels 4 core processes tied to cellular health:

1. Mitochondrial Energy ProductionNAD⁺ is rate-limiting for the electron transport chain (Complex I/III/IV).  NMN restores mitochondrial ATP output in aged muscle (12% ↑ in humans, 8 weeks, 300 mg/d) and reduces ROS leakage.

2. DNA Repair & Genomic StabilityNAD⁺ activates PARP-1 (poly ADP-ribose polymerase) for base-excision repair.

NMN (500 mg/d, 60 days) ↓ DNA damage markers (8-oxo-dG) by 25% in prediabetic women.

3. Sirtuin Activation (SIRT1–7)Sirtuins deacetylate histones, FOXO3, PGC-1α → anti-aging gene expression.

NMN raises SIRT1 activity in mouse aorta equivalent to caloric restriction; human trials show ↑ SIRT1 in PBMCs at 250 mg/d.

4. Senescence & Inflammation ControlNAD⁺ depletion drives SASP (senescence-associated secretory phenotype).

NMN (1 g/d, 12 weeks) ↓ p16^INK4a^ senescent cells in adipose tissue; lowers IL-6 by 30% in older adults.

Safety & Bioavailability No serious adverse events up to 1,200 mg/d (FDA GRAS review 2024).

Sublingual/buccal NMN bypasses liver first-pass; liposomal forms reach cells 2–3× better than capsules.

Practical Protocol (Evidence-Based)

1. Dose: 500–1,000 mg/d (split AM/PM to mimic NAD⁺ circadian peak).
2. Stack: 1 g TMG (trimethylglycine) to replenish methyl groups; 10 mg pterostilbene (SIRT1 cofactor).
3. Timing: With first meal to blunt insulin spike; avoid high-dose niacin (>50 mg) same day.
4. Cycle: 12 weeks on, 2 weeks off to prevent feedback inhibition of NAMPT.

Bottom line: NMN robustly raises NAD⁺, directly supporting mitochondrial function, DNA repair, and sirtuin signaling—core pillars of cellular resilience. Effects compound after 8–12 weeks; pair with resistance training for maximal mitochondrial biogenesis.