Liposomal NAD
$100.00
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Liposomal NAD
$100.00
What is NAD?
Nicotinamide adenine dinucleotide (NAD), often referred to as NAD+, is a vital coenzyme found in every cell of the body. It plays a central role in energy production, DNA repair, gene expression, and cellular signaling by facilitating redox reactions and activating enzymes like sirtuins and PARPs. NAD levels naturally decline with age—by up to 50% or more in some tissues— contributing to metabolic issues, inflammation, and age-related diseases. This decline can be exacerbated by factors like poor diet, stress, and chronic conditions. To counteract this, NAD+ precursors such as nicotinamide riboside (NR), nicotinamide mononucleotide (NMN), and nicotinamide (NAM) are commonly used in supplements or IV therapies. While animal studies show promising results, human evidence is emerging but limited to small trials. Larger clinical studies are needed to confirm benefits, and NAD supplementation is generally considered safe at recommended doses (e.g., 250–1,000 mg/day for precursors), though consulting a healthcare provider is advised, especially for those with medical conditions.
Key Health Benefits of NAD
Based on current research, here are the primary potential benefits of boosting NAD levels through supplements or therapy:
|
Benefit |
Description |
Supporting Evidence |
|
Anti-Aging and Longevity |
NAD+ activates sirtuins, which regulate cellular repair, reduce inflammation, and mimic benefits of calorie restriction or exercise, potentially slowing age-related decline. |
Animal studies show improved lifespan and healthspan; human trials with NR/NMN suggest modest extensions in metabolic markers but not yet longevity. |
|
Improved Energy and Metabolism |
Enhances mitochondrial function for better ATP production, supporting fat burning, insulin sensitivity, and weight management. |
Rodent studies link NMN to reduced obesity and better glucose control; small human trials report ~10% NAD increase but mixed functional outcomes. |
|
Cognitive and Brain Health |
Protects neurons from oxidative stress, supports neurotransmitter balance, and may reduce risks of Alzheimer's or dementia. |
Preclinical data shows neuroprotection; human studies indicate potential for better focus and mood, with ongoing trials for neurodegenerative conditions. |
|
Cardiovascular Health |
Reduces arterial stiffness, oxidative stress, and hypertension risk by improving vascular SIRT1 activity. |
Mouse models demonstrate better heart function and blood flow; early human data supports cholesterol and blood pressure improvements. |
|
Skin and Cellular Repair |
Aids DNA repair from UV damage, boosts collagen, and slows cell overgrowth in conditions like psoriasis. |
Topical and oral NAD shows anti-aging skin effects in small studies; linked to reduced inflammation. |
|
Mental Health and Addiction Support |
Balances brain chemistry to alleviate anxiety, depression, and cravings; aids recovery by repairing addiction-related damage. |
Clinical use in IV therapy reports reduced symptoms; rodent data supports relapse prevention. |
How to Boost NAD Levels
- Supplements: NR (e.g., 300 mg/day) or NMN (investigational, not FDA-approved as a supplement in some regions) are popular. Start low to monitor tolerance.
- Lifestyle: Exercise, intermittent fasting, and niacin-rich foods (e.g., fish, nuts) naturally elevate NAD.
- Therapy: IV NAD infusions provide rapid boosts but are more invasive and costly.
While exciting, NAD's full potential awaits more robust human data. If you're considering supplementation, prioritize evidence-based sources and professional guidance to weigh personal risks and benefits.