Liposomal Fisetin
$100.00
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Liposomal Fisetin
$100.00
What is Fisetin?
Fisetin is a naturally occurring flavonoid, a type of plant-based polyphenol with potent antioxidant properties. It's found in various fruits and vegetables, such as strawberries (the richest source at about 160 mg/kg), apples (27 mg/kg), persimmons, grapes, onions, and cucumbers. This compound helps combat oxidative stress by neutralizing free radicals and has been studied for its role in cellular health.
What is Liposomal Fisetin? Liposomal fisetin is a supplement form where fisetin is encapsulated in liposomes—tiny, double-layered "bubbles" made from natural phospholipids (like those from sunflower lecithin). This technology protects the fisetin from digestive breakdown, enhances its absorption into the bloodstream, and allows better delivery to cells and tissues. Standard fisetin has poor bioavailability (only a small fraction is absorbed), but liposomal versions can increase it significantly—up to 25 times in some formulations. This makes it more effective for potential health benefits compared to regular fisetin supplements or food sources alone.
Key Benefits of Liposomal Fisetin Research, primarily from animal studies, cell cultures, and early human trials, suggests fisetin (especially in bioavailable forms like liposomal) offers several promising benefits. While human evidence is emerging and not conclusive, here's a summary of the main ones:
|
Benefit |
Description |
Supporting Evidence |
|
Senolytic (Anti-Aging) Effects |
Clears out senescent ("zombie") cells that accumulate with age, promoting tissue repair and reducing age-related decline. May extend healthspan and lifespan. |
In mice, fisetin increased lifespan by 10% and reduced age-related issues. Early human trials (e.g., Mayo Clinic) use doses around 20 mg/kg to target this. Liposomal delivery maximizes cellular penetration for better results. |
|
Antioxidant Protection |
Neutralizes free radicals, protects cells from oxidative damage, and supports overall cellular health. |
Fisetin's structure gives it high antioxidant capacity; it binds well to liposome membranes for efficient delivery. May mimic calorie restriction benefits for longevity. |
|
Anti-Inflammatory Effects |
Reduces chronic inflammation linked to diseases like arthritis and heart issues. |
Inhibits inflammatory pathways in animal models; paired with quercetin in some formulas for enhanced sirtuin activation (proteins that regulate inflammation and aging). |
|
Brain Health and Neuroprotection |
Improves memory, cognitive function, and protects against neurodegenerative diseases like Alzheimer's. |
Animal studies show better memory retention and reduced dementia markers; may cross the blood-brain barrier more effectively in liposomal form. |
|
Anticancer Potential |
Induces apoptosis (cell death) in cancer cells and inhibits tumor growth. |
Epidemiological links to fruit-rich diets lowering cancer risk; lab studies show it targets proliferation in various cancers, though human data is limited and inconsistent. |
|
Metabolic Support (for Diabetes/Obesity) |
Helps regulate blood sugar, reduces insulin resistance, and supports weight management. |
Benefits type 2 diabetes in animal models; may improve metabolic health by reducing inflammation and oxidative stress in fat tissues. |
|
Immune and Skin Health |
Boosts immune function and protects skin from UV damage and aging. |
Antioxidant effects scavenge toxins; topical or oral use may prevent skin damage and support rejuvenation. |
Dosage and Usage Tips
- Typical Dose: 100–500 mg of fisetin per day, often split into 1–2 capsules. Liposomal products (e.g., 150 mg per serving) are common for optimal absorption. Take with a meal containing fats to boost uptake.
- Forms: Often combined with quercetin for synergy. Start low and consult a doctor, especially if you have conditions or take medications.
- Sources: Beyond supplements, eat more strawberries (about 1 cup provides ~160 mg) or other fisetin-rich foods.
Potential Side Effects and Considerations Fisetin is generally safe at recommended doses, with no major side effects reported in studies. However, high doses might cause mild digestive upset. It's not a substitute for medical treatment—ongoing research (including 2025 trials) is clarifying long-term human benefits. Always check for interactions and buy from reputable brands with third-party testing. If you're pregnant, nursing, or on blood thinners, seek professional advice.